Web(R)-(-)-Phenylephrine hydrochloride has been used: in the preparation and culturing of cardiocytes and fibroblasts; to stimulate myocardial strips to measure slice contraction; in primary cardiomyocyte culture to show the effect of Kruppel-like factors (KLF) on cardiac hypertrophy in vivo WebFeb 17, 2024 · Phenylephrine is a pure alpha1 agonist that will increase systemic vascular resistance without increasing heart rate or contractility. This is advantageous in patients with obstructive hypertrophic cardiomyopathy and hypotension since increases in both heart rate and contractility may cause the obstruction to worsen, leading to a decrease in ...
Phenylephrine - an overview ScienceDirect Topics
WebTo investigate the modulation of CO2 and endothelium of vascular contraction induced by various agonists, we studied the influence of high PCO2 (PCO2 = 91 mmHg, pH = 6.99) on the response of endothelium-intact and -rubbed rat aortic preparations to KCl, phenylephrine (PE), and human-porcine endothelin-1 (ET-1). WebFeb 19, 2024 · The most common catecholamine-active medications are phenylephrine, norepinephrine, and epinephrine. Other agents in this class include isoproterenol, dobutamine, and dopamine. Each of these three … persinfo halle
(R)-(−)-Phenylephrine powder 61-76-7 - Sigma-Aldrich
WebJul 31, 2024 · In patients with mild to moderate upper eyelid ptosis, phenylephrine eyedrops are used to assess whether ptosis correction is achievable with a Müller's muscle-conjunctival resection (MMCR). As an alpha-adrenergic agonist, phenylephrine stimulates the sympathetically innervated Müller's muscle when applied topically. WebPhenylephrine is an alpha1 agonist with very little beta effect. Its major action is systemic and pulmonary arterial vasoconstriction, increasing SVR and systemic arterial pressure (systolic, diastolic, and mean). Reflex bradycardia can occur. The increase in pulmonary artery pressure is less pronounced than the increase in aortic pressure. WebPhenylephrine is generally regarded as a "pure" alpha (1)-agonist. However, after treatment of the forearm with the alpha-adrenergic-blocking drug phentolamine, brachial artery infusion of phenylephrine can cause transient forearm vasodilation. To determine whether this response was beta-receptor mediated, phenylephrine, phentolamine, and ... pers information