WebERBB2 (HGNC Symbol) UniProtKB This gene has proteins that correspond to the following UniProtKB identifiers: P04626 CCDS This gene is a member of the Human CCDS set: CCDS32642.1, CCDS45667.1 Ensembl version ENSG00000141736.9 Other assemblies This gene maps to 39,687,914-39,730,426 in GRCh38 coordinates. Gene type Protein … Web8 Jun 2000 · ERBB2 is an orphan receptor activated by heterodimerization with other EGFR family members that interact with epidermal growth factor (EGF), EGF-like ligands and neuregulins.
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WebAnti-Human CD340/ERBB2/HER2/NEU Antibody (A21) (FHC09630) specific references (0) DATASHEET. Host species：Mouse Isotype：IgG2a, kappa ... Tyrosine kinase-type cell surface receptor HER2, NEU, MLN 19, Proto-oncogene Neu, MLN19, ERBB2, Proto-oncogene c-ErbB-2, CD340, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph … WebHuman ErbB2 consists of 1255 amino acids (aa) including a 22 aa signal sequence, a 630 aa extracellular domain (ECD), a 23 aa transmembrane region, and a 580 aa cytoplasmic domain. Within the ECD, human ErbB2 shares and 86% aa sequence identity with mouse and rat ErbB2. Phosphoinositide 3-kinase has been shown to play a role in ErbB2 signal ...
WebDescripción general. Anti-c-ErbB2/c-Neu (Ab-3), mouse monoclonal, clone 3B5, recognizes the ~185 kDa c-ErbB2/c-Neu protein in HEK293 cells. It is validated for WB, IF, IP, and IHC on frozen and paraffin sections. Purified mouse monoclonal antibody generated by immunizing BALB/c mice with the specified immunogen and fusing splenocytes with Sp2 ...
WebExpression of ERBB2 in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. ... The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation. ... WebAntibodies that detect Her-2 (ErbB2) can be used in several scientific applications, including Immunohistochemistry, Western Blot, Immunocytochemistry, Flow Cytometry and …
Receptor tyrosine-protein kinase erbB-2 is a protein that in humans is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. The human protein is also frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 (cluster of differentiation 340).
Web6 Apr 2024 · Introduction. Trastuzumab is a monoclonal antibody binding to the extracellular juxtamembrane domain of ERBB2. Trastuzumab has been the standard of care for the treatment of patients with ERBB2-positive breast cancer and ERBB2-positive advanced gastric cancer due to its effectiveness and favorable toxicity profile. 1 Although … department stores apush definitionWebHuman Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. fh they\u0027dWeb21 Mar 2024 · ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with ERBB2 include Visceral Neuropathy, Familial, 2, Autosomal … fh they\\u0027veWeb2 Mar 2024 · The epidermal growth factor receptor (EGFR) family member erb-b2 receptor tyrosine kinase 2 (ERBB2) is overexpressed in many types of cancers leading to (radio- and chemotherapy) treatment resistance, whereas the underlying mechanisms are still unclear. Autophagy is known to contribute to cancer treatment resistance. In this study, we … department store photographyWebPepMix™ Human (ErbB2_ECD) US$649.00 Excluding tax and shipping fees In stock Add to Cart Description Product Description Pool of 161 peptides derived from a peptide scan … fh they\\u0027llWebc-erbB-2 Oncoprotein (Concentrate) Clone Polyclonal. A synthetic peptide, coupled to keyhole limpet hemocyanin, has been used for immunization. The peptide represents part of the predicted 185 kDa oncoprotein encoded by ERBB2, also termed HER2 or NEU. The antibody recognizes an epitope on the cytoplasmic part of the cell membrane-bound c … fh they\u0027reWebThe erbB2/HER-2 protein has been shown to interact with a large number of proteins, including SHC1, EGF receptorm, neuroregulin 1, c-Src, integrin β4, Grb2, Grb7, SOS1, caveolin 1, JAK2, PAK1, FAK, and β-catenin, among others. CD340 is extensively modified by tyrosine phosphorylation on multiple residues (Y1023, Y1139, Y1196, Y1221, Y1222, … fh they\\u0027re