WebJan 9, 2015 · Cryptotanshinone (CTS) is a major bioactive diterpenoid isolated from Danshen, an eminent medicinal herb that is used to treat cardiovascular disorders in Asian medicine. However, it is not known whether CTS can prevent experimental atherosclerosis. WebThe nature of intestinal absorption of most herbal medicine is unknown. Cryptotanshinone (CTS) is the principal active constituent of the widely used cardiovascular herb Salvia miltiorrhiza (Danshen). We investigated the oral bioavailability of CTS in rats and the mechanism for its intestinal absorption using several in vitro and in vivo models: 1) Caco …
Cryptotanshinone induces cell cycle arrest and apoptosis through …
WebCryptotanshinone (CTS) was identified as a potent STAT3 inhibitor, while the effect of other tanshinones remains unknown. METHODS AND RESULTS: In this study, the influence of eight tanshinones on STAT3 activity was initially screened and Isocryptotanshinone (ICTS) significantly inhibited STAT3 activity in a dual luciferase assay. WebAs a natural compound derived from the roots of Salvia miltiorrhizaBunge (Danshen), cryptotanshinone (CTS) could significantly inhibit the phosphorylation and dimerization of signal transducer and activator of transcription 3 (STAT3),22which has been commonly utilized in traditional medicine to treat circulatory disorders, hepatitis, and chronic … hnnjl
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WebCryptotanshinone (CTS) is a herbal medicine and has been identified as an anti-inflammatory and anti-oxidative drug. Methods: In vitro assays, including the cell … WebCryptotanshinone is a natural quinoid diterpene first isolated from Salvia miltiorrhiza roots, which are used in traditional Chinese medicine for a variety of conditions. 1 … Web解 芸 菲 (河北化工医药职业技术学院 制药工程系,河北 石家庄 050026) janus激酶(jak)家族,现已发现4个成员:jak1,jak2,jak3 及tyk1,是一类非受体酪氨酸激酶家族.其中,除tyk1主要存在于造血干细胞中外,jak1,jak2及jak3几乎在所有的细胞中均有表达[1].作为jak的底物,信号转导与转录激活因子(stat)家族 ... hnnjmm